社会挫败动物模型研究进展

Research progress on animal models of social defeat

社会挫败应激是以物种间的从属关系为基础的社会应激方式,它通过同种动物相同或不同品系个体间的挫败行为导致抑郁样及其他行为改变。目前,抗社会挫败药物研究较少,现有动物模型存在一定的缺陷,且无统一标准。本文就近年来社会挫败动物模型应用的研究及其发病机制进行综述,为开发抗社会挫败药物提供可供参考的动物模型。

Social defeat stress is a social stress method based on the subordination relationship between species. It leads to depression-like and other behavioral changes through frustrating behaviors between individuals of the same animal or different strains. Currently, few studies examine anti-social defeat drugs and the existing animal models have certain shortcomings and there is no uniform standard. This article reviews recent research on the application of social defeat animal models and their pathogenesis and provides a reference animal model for the development of anti-social defeat drugs.