MMP2在肿瘤侵袭和转移中的调控机制研究

The role of MMP2 in tumor invasion and metastasis

肿瘤的侵袭和转移与诸多因素相关,是造成癌症病人不良预后的重要原因。肿瘤发生转移的前提条件是突破细胞外基质(ECM)这一天然屏障。基质金属蛋白酶2(MMP2)具有独特的酶活性,有突破ECM的能力,可促进肿瘤转移的发生。在多种恶性肿瘤中,MMP2通过调节多种通路影响着肿瘤的浸润、转移及预后,很可能成为一种癌症转移预测的标志物。本文就MMP2在肿瘤侵袭和转移中的调控机制进行综述,以期为恶行肿瘤的诊断和治疗提供新的靶点。

A poor prognosis in cancer patients is closely related to tumor invasion and metastasis, which is affected by many factors. A prerequisite for tumor metastasis is the breakdown of the extracellular matrix(ECM), which is a natural cellular barrier. Matrix metalloproteinase-2(MMP2) has a unique enzymatic activity with the ability to break through the ECM, which may promote tumor metastasis. MMP2 influences tumor invasion, metastasis and patient prognosis through various regulatory pathways in different malignant tumors and may be a marker for predicting cancer metastasis. This review demonstrates the role of MMP2 in tumor invasion and metastasis and proposes MMP2 as a new target for the diagnosis and treatment of malignant tumors.