淋巴瘤患者生殖保护现状与展望

Status and prospect of reproductive protection in patients with lymphoma

目前化疗联合放疗、靶向治疗是治疗淋巴瘤的主要手段,但临床相关治疗措施在使患者获得疾病缓解和长期生存的同时亦对其生殖功能产生负面影响。对于疗效好、获得长期生存及缓解的年轻患者,能否正常生育成为淋巴瘤长远预后评价的重要方面,亦是淋巴瘤患者关心的问题。文章从淋巴瘤的流行病学、淋巴瘤对生殖功能的影响、淋巴瘤患者生殖功能保护的现状与挑战、人类生殖伦理问题以及淋巴瘤患者生殖保护原则和选择等方面进行探讨,以期为我国淋巴瘤患者的生殖保护与优生优育提供参考。

At present,chemotherapy combined with radiotherapy or targeted therapy is the key method for the treatment of lymphoma.However,clinical treatment measures are not only effective for patients to obtain disease remission and long-term survival,but also have a negative impact on reproductive function of patients.For young patients with good curative effects,long-term survival and remission,normal childbearing becomes an important aspect of long-term prognosis evaluation of lymphoma,and it is also a concern of lymphoma patients.This article will systematically present the epidemiology of lymphoma,the impact of lymphoma on reproductive function,the status and challenges of reproductive function protection in lymphoma patients,the ethical issues of human reproduction,and the principles and selection of reproductive protection for patients with lymphoma.The analysis and discussion are expected to provide reference for the reproductive protection and eugenics of lymphoma patients in China.