儿童骺板损伤组织工程学治疗研究进展

Advances in tissue engineering treatment of epiphyseal plate injury in children

儿童骺板损伤非常常见,骨折、感染、恶性肿瘤或医源性损伤等原因均可导致,损伤后易引起生长阻滞、成角或旋转畸形,严重影响儿童的身心健康。目前临床骨桥切除术结合相应材料填充的治疗方法成功率低。采用软骨组织工程技术构建具有生物活性的骺板软骨成为治疗儿童骺板损伤新的研究方向。因此,现主要从组织工程三要素:种子细胞、生长因子、组织工程支架角度对目前骺板软骨的再生研究进行综述。

Epiphyseal plate injury in children is very common,which can be caused by fracture,infection,malignant tumors,iatrogenic injury or other causes.Growth arrest and angulation or rotation deformity after epiphyseal plate injury would seriously affect the physical and mental health of children.At present,the success rate of bone bridge resection combined with corresponding material filling is super low.The construction of bioactive epiphyseal cartilage using cartilage tissue engineering technology has become a new research direction for the treatment of epiphyseal plate injury in children.Therefore,this review focuses on the current research on the regeneration of epiphyseal cartilage from the perspective of 3 elements of tissue engineering:seed cells,growth factors,and tissue engineering scaffolds.