铜绿假单胞菌异质性耐药的研究进展

Research progress on heteroresistance of Pseudomonas aeruginosa

异质性耐药是指细菌中的同源亚群对某种抗生素表现出不同的敏感性,被认为是细菌由敏感进化成完全耐药的中间阶段。常规的临床检验无法有效检测出异质性耐药,这对临床治疗用药造成了巨大的威胁,引起患者的反复感染和用药失败。铜绿假单胞菌作为医院内感染的主要条件致病菌之一,其耐药机制已被广泛研究,而异质性耐药研究则相对较少。本文主要就铜绿假单胞菌的异质性耐药研究进行了梳理,并对异质性耐药从表型特征、机制和检测方法等方面进行了简要阐明。

Heteroresistance refers to the different susceptibilities of homologous bacterial subgroups to an antibiotic,which is considered as the intermediate stage of bacterial evolution from susceptibility to resistance.Conventional clinical tests cannot effectively detect heteroresistance,which poses a serious threat to clinical treatment and medication,resulting in repeated infection and medication failure of patients.Pseudomonas aeruginosa is one of the main opportunistic pathogens causing nosocomial infection.Despite the extensive research on the drug resistance mechanism of P.aeruginosa,the studies about the heteroresistance of this bacterium are rare.In this review,we summarized the related studies about the heteroresistance of P.aeruginosa and expounded the phenotypic characteristics,mechanism,and detection methods of heteroresistance.