蛋白质组学在变应性鼻炎中的应用研究进展

Application of proteomics in allergic rhinitis

变应性鼻炎(AR)是指以IgE介导为主的Ⅰ型变态反应,它主要由肥大细胞、嗜酸粒细胞等炎症细胞及IL-4、IL-5等细胞因子共同参与,以Th2细胞占优势的鼻黏膜炎性疾病[1]。全球平均发病率高达40%左右,且呈逐年增高趋势[2],我国的患病率从2005年的11.1%上升至2011年的17.6%[3-4]。目前,AR的诊断主要依据临床症状(流鼻涕、鼻塞、鼻痒、打喷嚏)、常见体征(鼻黏膜苍白、水肿,鼻腔水样分泌物等)及过敏原检测等方法[5-7]。

The prevalence of allergic rhinitis(AR)is increasing year by year, which seriously affects the quality of life of patients and causes a heavy burden of social diseases. At present, the diagnosis methods focus on clinical manifestations and allergen detection, but there is no accurate detection method for early diagnosis and prognosis of the disease. With the rapid development of proteomics technology and its wide application in disease research, there is a rapid, sensitive and high-throughput technology platform for the diagnosis and treatment of allergic rhinitis, which provides a platform for the early detection, therapeutic targets and prognosis of the disease. This article reviews the progress of AR in proteomics.