改良电抽搐疗法联合第二代抗精神药物治疗精神分裂症的疗效分析

Curative effect of modified electric convulsive treatment combined with second-generation anti-psychotics on schizophrenia

目的探讨改良电抽搐疗法(MECT)联合第二代抗精神药物治疗精神分裂症的临床疗效及安全性。方法118例精神分裂症患者随机均分为联合组和对照组。对照组采用第二代抗精神药物治疗,联合组在对照组基础上行MECT治疗。评估两组临床疗效,记录治疗前、治疗后2、4、6周阴性和阳性症状量表(PANSS)评分,记录治疗前、后临床记忆量表(CMS)评分、日常生活能力量表(ADL)评分及治疗期间不良反应发生情况。结果联合组总有效率明显高于对照组(P<0.05)。治疗后,两组PANSS评分和ADL评分低于治疗前,且联合组低于对照组(P<0.05)。治疗后,两组CMS评分高于治疗前(P<0.05),但组间差异无显著性(P>0.05)。两组不良反应发生率差异无显著性(P>0.05)。结论MECT联合第二代抗精神药物治疗精神分裂症的疗效较单纯药物治疗更优,且安全性较高。

Aim To explore the clinical effect and safety of modified electric convulsive treatment(MECT)combined with second-generation anti-psychotics in the treatment of schizophrenia.Methods A total of 118 patients with schizophrenia were randomly divided into combination group and control group,59 cases in each group.The control group was treated with second-generation anti-psychotics,while combination group was additionally treated with MECT.The clinical curative effect in both groups was evaluated.The scores of positive and negative syndrome scale(PANSS)before treatment,at 2,4 and 6 weeks after treatment,scores of Clinical Memory Scale(CMS)and Activity of Daily Living Scale(ADL)before and after treatment,and occurrence of adverse reactions during treatment were recorded.Results The total response rate in combination group was significantly higher than that in control group(P<0.05).After treatment,scores of PANSS and ADL in both groups were decreased,which were lower in combination group than control group(P<0.05).After treatment,CMS scores in both groups were increased(P<0.05),but the difference between the two groups was not statistically significant(P>0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of MECT combined with second-generation antipsychotics is better than that of single medication on schizophrenia,with higher safety.