摘要
线粒体自噬是指自噬小体选择性地将受损线粒体包裹并转运至溶酶体水解的过程,参与线粒体的质量控制及细胞稳态的维持。心脏作为机体的“泵”器官,需要充足的能量以满足心肌细胞的收缩功能,当线粒体自噬不足时可能会致使心肌细胞受损,从而介导心脏疾病的发生。因此,现针对线粒体自噬的分子生物学过程及其在心脏疾病中的作用展开综述,以期为心脏疾病的治疗手段提供新思路。
Mitophagy is a process that autophagosome selectively package and transport damaged mitochondria to lysosome for hydrolysis,which participate in the quality control of mitochondria and maintenance of cell homeostasis.As a“pump”organ,the heart needs sufficient energy to meet the contractile function of cardiomyocytes,and insufficient mitophagy can lead to abnormal mitochondrial accumulation and cause heart diseases.This article will review the process of mitophagy and its role in heart diseases,thus providing new ideas for the treatments of heart diseases.
作者
李开
饶莉
LI Kai;RAO Li(Department of Cardiology,West China Hospital of Sichuan University,Chengdu 610041,Sichuan,China)
出处
《心血管病学进展》
CAS
2022年第3期222-224,228,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(82071735)。
