射血分数保留性心力衰竭:从机制到治疗

Heart Failure with Preserved Ejection Fraction:from Mechanism to Treatment

射血分数保留性心力衰竭是一个全球性的重大公共卫生问题。它是一种异质性综合征,由于复杂的病理机制和缺乏单一的诊断标准,其诊断及治疗具有挑战性。目前还无公认的能改变射血分数保留性心力衰竭临床进程的治疗方法。现阐述射血分数保留性心力衰竭潜在的发病机制及治疗靶点,以期为该病的基础及临床治疗提供研究思路。

Heart failure with preserved ejection fraction(HFpEF)is a major global public health question.It is a heterogeneous syndrome,and its diagnosis and treatment are challenging due to complex pathological mechanisms and lack of a single diagnostic standard.At present,there is no generally recognized treatment method that can change the clinical course of HFpEF.This article aims to describe the potential pathophysiological mechanism and therapeutic targets of HFpEF,in order to provide research ideas for the basic and clinical treatment of the disease.