银杏二萜内酯葡胺联合丁苯酞治疗超早期脑梗死患者的效果

Effects of Ginkgo diterpene lactone meglumine combined with Butylphthalide in treatment of patients with super-early cerebral infarction

目的:观察银杏二萜内酯葡胺联合丁苯酞治疗超早期脑梗死患者的效果。方法:选取85例超早期脑梗死患者为研究对象,按照随机数字表法将其分为观察组42例和对照组43例。两组患者均给予阿替普酶静脉溶栓,在此基础上对照组予以丁苯酞氯化钠注射液治疗,观察组则在对照组基础上加用银杏二萜内酯葡胺注射液治疗。比较两组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平、炎性因子[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]水平及不良反应发生情况。结果:观察组治疗总有效率为90.48%(38/42),高于对照组的72.09%(31/43),差异有统计学意义(P<0.05);观察组治疗后6 h、1 d及14 d时的NIHSS评分均低于对照组,差异有统计学意义(P<0.05);观察组治疗后SOD水平高于对照组,而MDA、hs-CRP及IL-6水平均低于对照组,差异有统计学意义(P<0.05);两组均未发生明显不良反应。结论:在阿替普酶静脉溶栓后,采用银杏二萜内酯葡胺联合丁苯酞治疗超早期脑梗死患者效果较好,能减轻神经功能缺损和氧化应激反应,降低炎性因子水平,效果优于单用丁苯酞治疗。

Objective:To study effects of Ginkgo diterpene lactone meglumine combined with Butylphthalide in treatment of patients with super-early cerebral infarction.Methods:85 patients with super-early cerebral infarction were selected as the research objects,and were divided into observation group(42 cases)and control group(43 cases)according to the random number table method.Both groups were given Alteplase intravenous thrombolysis.On this basis,the control group was treated with Butylphthalide and sodium chloride injection,while the observation group was additionally treated with Ginkgo diterpene lactone meglumine injection.The clinical efficacy,the national institutes of health stroke scale(NIHSS)score,the oxidative stress indexes[superoxide dismutase(SOD),malondialdehyde(MDA)]levels,the inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)]levels and the adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 90.48%(38/42),which was higher than the control group of 72.09%(31/43),and the difference was statistically significant(P<0.05).The NIHSS scores of the observation group 6 h,1 d and 14 d after the treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the SOD level in the observation group was higher than that in the control group,while the levels of MDA,hs-CRP and IL-6 were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there were no obvious adverse reactions in both groups.Conclusions:After Alteplase intravenous thrombolysis,Ginkgo diterpene lactone meglumine combined with Butylphthalide in the treatment of the patients with super-early cerebral infarction can achieve ideal results,which can reduce the neurological deficits and oxidative stress,and reduce the inflammatory factor levels.Moreover,it is superior to single Butylphthalide.