喜炎平注射液联合头孢吡肟治疗小儿支气管肺炎的效果

Effects of Xiyanping injection combined with Cefepime in treatment of children with bronchopneumonia

目的:观察喜炎平注射液联合头孢吡肟治疗小儿支气管肺炎的效果。方法:选取70例支气管肺炎患儿为研究对象,按照随机数字表法分为对照组与观察组各35例。对照组采用头孢吡肟治疗,观察组采用喜炎平注射液联合头孢吡肟治疗。比较两组治疗7 d后的临床疗效、症状消失时间、治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、FEV_(1)/用力肺活量(FVC)]水平和血气指标[动脉血氧分压(PaO_(2))]水平、血清学指标[白细胞介素-6(IL-6)、血清淀粉样蛋白A(SAA)、红细胞沉降率(ESR)]水平及不良反应发生率。结果:观察组治疗总有效率为97.14%(34/35),高于对照组的77.14%(27/35),差异有统计学意义(P<0.05);观察组发热、咳嗽、肺部啰音消失时间及肺部X线炎症吸收时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组FEV_(1)、FEV_(1)/FVC、PaO_(2)水平均高于对照组,血清IL-6、SAA、ESR均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:喜炎平注射液联合头孢吡肟治疗小儿支气管肺炎能促进症状缓解,改善肺功能指标和血氧指标水平,降低血清IL-6、SAA、ESR水平,且安全性良好。

Objective:To observe effects of Xiyanping injection combined with Cefepime in treatment of children with bronchopneumonia.Methods:70 children with bronchopneumonia were selected as the research objects and were divided into control group and observation group according to the random number table method,35 cases in each group.The control group was treated with Cefepime,while the observation group was treated with Xiyanping injection combined with Cefepime.The clinical efficacy,the symptom relief time,the pulmonary function indicator levels[forced expiratory volume in 1 second(FEV_(1)),FEV_(1)/forced vital capacity(FVC)],the blood gas indicator levels[arterial partial pressure of oxygen(PaO_(2))],the serological indicator levels[interleukin-6(IL-6),serum amyloid A(SAA),erythrocyte sedimentation rate(ESR)]and the incidence of adverse reactions were compared between the two groups 7 days after the treatment.Results:The total effective rate in the observation group was 97.14%(34/35),which was higher than 77.14%(27/35)in the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,cough and pulmonary rales and the absorption time of lung X-ray inflammation in the observation group were all shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV_(1),FEV_(1)/FVC,and PaO_(2) in the observation group were higher than those in the control group;the levels of serum IL-6,SAA and ESR were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xiyanping injection combined with Cefepime in the treatment of the children with bronchopneumonia can accelerate the symptom relief,improve the pulmonary function indicator levels and the blood oxygen indicator level,and reduce the serum IL-6,SAA and ESR levels with good safety.