补肾壮骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折患者的效果

Effects of Bushen Zhuanggu decoction combined with vertebroplasty in treatment of elderly patients with osteoporotic thoracolumbar compression fractures

目的:观察补肾壮骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折患者的效果。方法:选取92例老年骨质疏松性胸腰椎压缩性骨折患者为研究对象,按随机数字表法将其分为观察组与对照组各46例。对照组采用经皮椎体成形术治疗,观察组在对照组基础上采用补肾壮骨汤治疗,比较两组临床疗效、疼痛程度、腰部功能障碍评分、椎体结构指标水平、骨密度和骨代谢指标水平。结果:观察组治疗总有效率为95.65%,明显高于对照组的73.91%,差异有统计学意义(P<0.05);治疗后,观察组视觉模拟评分法(VAS)评分和Oswestry功能障碍指数(ODI)评分均低于对照组,差异有统计学意义(P<0.05);观察组椎体前缘高度、中线高度、后缘高度均高于对照组,Cobb角小于对照组,差异均有统计学意义(P<0.05);观察组骨密度、骨钙素和骨碱性磷酸酶水平均高于对照组,差异有统计学意义(P<0.05)。结论:补肾壮骨汤联合椎体成形术治疗老年骨质疏松性胸腰椎压缩性骨折患者可提高治疗总有效率、骨密度水平和骨代谢指标水平,改善椎体结构指标水平,以及降低VAS和ODI评分,其效果优于单纯经皮椎体成形术治疗。

Objective:To observe effects of Bushen Zhuanggu decoction combined with vertebroplasty in treatment of elderly patients with osteoporotic thoracolumbar compression fractures.Methods:92 elderly patients with osteoporotic thoracolumbar compression fractures were selected as the research objects,and were divided into observation group and control group according to the random number table method,46 cases in each.The control group was treated with percutaneous vertebroplasty,while the observation group was treated with Bushen Zhuanggu decoction on the basis of that of the control group.The clinical efficacy,the pain severity score,the lumbar dysfunction score,the vertebral body structure index levels,the bone mineral density and the bone metabolism index levels were compared between the two groups.Results:The total effective rate of the observation group was 95.65%,which was significantly higher than the control group of 73.91%,and the difference was statistically significant(P<0.05).After the treatment,the visual analogue scale(VAS)score and the Oswestry disability index(ODI)score of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The anterior height,the midline height,and the posterior height of the observation group were higher than those of the control group;the Cobb angle was smaller than that of the control group;and the differences were statistically significant(P<0.05).Further,the levels of bone mineral density,osteocalcin and bone alkaline phosphatase in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Bushen Zhuanggu decoction combined with vertebroplasty in the treatment of the elderly patients with osteoporotic thoracolumbar vertebral compression fractures can improve the total effective rate,the bone mineral density and the bone metabolism index levels,improve the vertebral body structure index levels,and reduce the VAS and the ODI score.Moreover,it is superior to single percutaneous vertebroplasty.