不同性别首发未用药精神分裂症患者血清VEGF水平与临床症状的相关性

Correlation between serum VEGF level and clinical symptoms in patients with first-episode drug-naive schizophrenia of different genders

目的探讨不同性别首发未服药精神分裂症患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)水平及其与临床症状的相关性。方法纳入2016年1月至2019年10月就诊的首发未服药精神分裂症患者81例(患者组,男41例,女40例),健康对照64名(对照组,男40例,女24例)。血清VEGF水平采用流式多重蛋白分析技术(cytometric bead array,CBA)测定;使用阳性与阴性症状量表(positive and negative syndrome scale,PANSS)评定患者相关临床症状。采用SPSS 22.0进行统计分析。组间比较采用独立样本t检验、非参数检验,VEGF与临床变量关系采用Pearson相关分析和Spearman相关分析。结果患者组血清VEGF水平明显低于对照组[148.08(75.89,208.61)pg/mL,179.94(99.14,318.41)pg/mL,Z=-2.20,P=0.028];男性患者的PANSS总分[(82.71±17.30)分,(73.45±16.36)分,t=2.473,P=0.016]和认知分[(7.88±3.36)分,(6.23±2.81)分,t=2.402,P=0.019]均高于女性患者。患者组VEGF水平与PANSS阴性症状评分呈负相关(r=-0.228,P=0.041),男性患者组VEGF水平和认知评分呈负相关(r=-0.425,P=0.007)。结论首发精神分裂症患者血清VEGF水平下降,并影响其阴性症状。男性首发精神分裂症患者血清VEGF可能对其认知功能有一定影响。

Objective To investigate the level of serum vascular endothelial growth factor(VEGF)and its correlation with clinical symptoms in patients with first-episode drug-naive schizophrenia patients of different genders.Methods From January 2016 to October 2019,a total of 81 first-episode drug-naive schizophrenia patients(patient group,41 male,40 female)and 64 healthy controls(control group,40 male,24 female)were included in this study.The serum level of VEGF was detected with flow cytometric bear array(CBA).Positive and negative symptom scale(PANSS)was used to evaluate the relevant clinical symptoms of patients.SPSS 22.0 software was used for statistical analysis.Independent sample t-test and nonparametric test were used for comparison between groups.The relationship between VEGF and clinical variables was analyzed by Pearson correlation analysis and Spearman correlation analysis.Results The level of serum VEGF in the patient group was significantly lower than that in the control group(148.08(75.89,208.61)pg/mL,179.94(99.14,318.41)pg/mL,Z=-2.20,P=0.028).The total PANSS score((82.71±17.30),(73.45±16.36),t=2.473,P=0.016)and cognitive score((7.88±3.36),(6.23±2.81),t=2.402,P=0.019)in male patients were higher than those in female patients.There was a negative correlation between VEGF level and PANSS negative symptom score in the patient group(r=-0.228,P=0.041),as well as significant negtive correlation between VEGF level and cognitive score in male patients(r=-0.425,P=0.007).Conclusion The level of serum VEGF is reduced in first-episode patients with schizophrenia,which influences their negative symptom.Moreover,the decline in serum VEGF level is implicated in cognitive impairments in male patients with first-episode schizophrenia.