幽门螺杆菌感染与慢性胃炎的相关性分析

Correlation analysis between Helicobacter pylori infection and chronic gastritis

目的分析幽门螺杆菌(Hp)感染与慢性胃炎(CG)的相关性,以期为慢性胃炎的临床诊断及治疗提供科学参考及理论依据。方法选取114例CG患者纳入观察组,另选取100例健康体检者纳入对照组。所有受检者均进行胃镜检查及快速尿素酶(RUT)试验。对比两组受检者Hp感染情况,对比观察组中不同类型CG患者的Hp感染情况,分析CG病位证素分布特征及其与Hp感染的相关性。结果观察组Hp感染阳性率74.56%高于对照组的18.00%,差异有统计学意义(P<0.05)。慢性浅表性胃炎、慢性糜烂性胃炎及胆汁反流性胃炎Hp感染阳性率对比,差异有统计学意义(P<0.05);慢性糜烂性胃炎Hp感染阳性率最高,其次为慢性浅表性胃炎,最后为胆汁反流性胃炎。观察组中Hp感染阳性患者病位证素主要为胃、脾、肝,分别占比88.24%、61.18%、29.41%;Hp感染阴性患者病位证素主要为胃、脾、肝,分别占比72.41%、37.93%、24.14%。CG病位证素胃、脾与Hp感染存在相关性(P<0.05)。结论Hp感染是导致慢性胃炎发生的重要因素,但并非所有慢性胃炎均由该病菌引起,而慢性胃炎伴Hp感染多与胃、脾两脏器存在紧密关联,故在针对慢性胃炎治疗中需强化对Hp感染的关注,并可通过运用证素辨证方法更加准确地把握患者病位及致病因素,从而予以针对性治疗,提升临床诊疗准确性及针对性。

Objective To analyze the correlation between Helicobacter pylori(Hp)infection and chronic gastritis(CG),so as to provide scientific reference and theoretical basis for the clinical diagnosis and treatment of chronic gastritis.Methods 114 cases of CG patients were selected as the observation group,and 100 healthy subjects were selected as the control group.All subjects underwent gastroscopy and rapid urease test(RUT).The Hp infections of the two groups were compared,and the Hp infections of different types of CG patients in the observation group were compared to analyze the distribution characteristics of CG syndrome evidence and its correlation with Hp infection.Results The positive rate of Hp infection 74.56% in the observation group was higher than 18.00% in the control group,and the difference was statistically significant(P<0.05).The positive rate of Hp infection in chronic superficial gastritis,chronic erosive gastritis and bile reflux gastritis was compared,and the difference was statistically significant(P<0.05).Chronic erosive gastritis had the highest positive rate of Hp infection,followed by chronic superficial gastritis and bile reflux gastritis.In the observation group,the main syndrome elements of patients with positive Hp infection were stomach,spleen and liver,accounting for 88.26%,61.18% and 29.41%,and the main pathologic elements were stomach,spleen and liver for patients with positive Hp infection,accounting for 72.41%,37.93% and 24.14%.There was a correlation between the CG syndrome evidence elements of stomach and spleen and Hp infection(P<0.05).Conclusion Hp infection is an important pathogenic factor leading to chronic gastritis,but not all chronic gastritis is caused by this bacteria;however,chronic gastritis with Hp infection is mostly closely related to the stomach and spleen,so in the treatment of chronic gastritis,the attention to Hp infection should be strengthened,and the patient's disease location and pathogenic factors can be more accurately grasped through the use of evidence-based dialectical methods,so that targeted treatment can be given to improve the accuracy and pertinence of clinical treatment.