线粒体损伤在支气管哮喘发生发展中的作用

Mitochondria dysfunction in the pathogenesis of bronchial asthma

支气管哮喘(哮喘)是一种以不同程度的气流阻塞、气道高反应性和气道炎症为特点的复杂炎症性疾病。线粒体损伤及功能障碍是哮喘重要的发病机制之一。了解线粒体结构、功能及其在哮喘中的作用机制,有助于在哮喘治疗中针对功能失调的线粒体开发新型靶向治疗药物。本文就线粒体功能及其在哮喘中的作用进行综述。

Bronchial asthma(asthma)is a kind of complex disease characterized by different degrees of airflow obstruction,airway hyperresponsiveness and airway inflammation.Mitochondrial dysfunction is one of the important pathogeneses of asthma.Understanding mitochondrial structure,function,and their participation in asthma will contribute to the treatment targeted at dysfunctional mitochondria.This paper will review mitochondrial function and its role in asthma.