摘要
呼出气一氧化氮目前被认为是气道嗜酸性炎症的重要生物标志物之一,因其操作简便性、无创性、安全性等优势,现广泛用于哮喘、变应性鼻炎、鼻窦炎等上下气道疾病的诊疗。本文就呼出气一氧化氮的基础生物学特性、测定方法、代表意义,及其与临床常见呼吸道过敏性疾病或少见罕见的基因相关疾病的关系和临床实际应用展开阐述。
Exhaled nitric oxide is currently considered as one of the important biomarkers of airway eosinophilic inflammation.Due to its advantages of simple operation,noninvasion and safety,it is widely used in the diagnosis and treatment of upper and lower airway diseases such as asthma,allergic rhinitis and nasosinusitis.This paper summarizes the basic biological characteristics,measurement and clinical significance of exhaled nitric oxide and its association with common airway allergic diseases or gene mutation-caused rare diseases and the clinical application.
作者
李鹏云
郝创利
Li Pengyun;Hao Chuangli(Department of Respiratory Medicine,Children′s Hospital of Soochow University,Suzhou 215000,China)
出处
《国际呼吸杂志》
2022年第6期464-469,共6页
International Journal of Respiration
基金
国家自然科学基金面上项目(82070009)
苏州市"临床医学专家团队"引进项目(SZYJTD201806)
苏州市科技发展计划医疗器械与新医药(临床试验)-医工结合协同创新研究项目(SLJ201905)。
