帕金森病的临床亚型研究进展

Research progress of clinical subtypes of Parkinson′s disease

帕金森病是一种高度异质性疾病,具有广泛的运动症状和非运动症状。帕金森病患者的临床特征、主要症状和进展速度因人而异,表明存在不同的临床亚型。帕金森病临床亚型的研究旨在了解这种异质性。文中总结了常用的帕金森病临床分型方案,探讨分型面临的挑战和未来的方向。在今后的研究中,通过设计标准化的研究方案、比较不同亚型之间潜在的生物标志物的差异,将有助于更好地理解潜在的疾病机制、预测预后以及制定个体化的治疗策略。

Parkinson′s disease(PD)is a widely heterogeneous disorder with a broad list of motor and nonmotor manifestations.PD varies in clinical features,dominant symptoms,and rate of progression from case to case,suggesting the existence of distinct subtypes.Research on PD subtypes aims to understand this heterogeneity.This review summarized the commonly used PD subtyping solutions and discussed the challenges and future perspectives of subtyping.In future study,by designing a more standardized research and comparing the differences of these subtypes in terms of a number of putative biomarkers,that might help to better understand the underlying disease mechanisms,predict prognosis,and eventually design more efficient personalized management strategies.