血清免疫球蛋白与白细胞介素18联合检测用于乙型病毒性肝炎患者的临床意义

Clinical significance of combined detection of serum immunoglobulin and interleukin-18 in patients with viral hepatitis B

目的分析血清免疫球蛋白联合白细胞介素18(IL-18)在乙型病毒性肝炎(乙肝)患者中的变化及临床意义。方法选取2019年9月至2020年9月济南市第二人民医院收治的乙肝患者102例作为观察组,另选同期健康体检者99例作为对照组,两组均行血清免疫球蛋白及IL-18水平检测,比较两组检测结果,分析观察组治疗前后血清免疫球蛋白及IL-18水平变化情况。结果对照组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、IL-18水平分别为(1.76±0.63)g/L、(11.58±3.46)g/L、(1.38±0.49)g/L、(1.68±0.34)μg/L,观察组分别为(2.68±0.74)g/L、(15.24±4.17)g/L、(2.59±1.03)g/L、(2.53±0.21)ng/mL,组间比较,观察组均高于对照组(t=9.45、6.74、10.54、21.36,均P<0.01);观察组治疗前IgA、IgG、IgM及IL-18水平分别为(2.68±0.74)g/L、(15.24±4.17)g/L、(2.59±1.03)g/L、(2.53±0.21)μg/L,治疗后分别为(2.03±0.51)g/L、(13.12±3.25)g/L、(1.93±0.47)g/L、(1.74±0.15)μg/L,治疗后IgA、IgG、IgM及IL-18水平均低于治疗前(t=7.26、4.02、10.54、5.87,均P<0.01)。结论血清免疫球蛋白联合IL-18能反映乙肝患者的病情状况,能为临床治疗提供科学参考。该研究成果具有科学性和创新性,值得推广。

Objective To detect serum immunoglobulin and interleukin-18(IL-18)levels in patients with viral hepatitis B and investigate the clinical significance of combined detection of serum immunoglobulin and IL-18 levels.Methods A total of 102 patients with viral hepatitis B who received treatment in Jinan 2nd People's Hospital from September 2019 to September 2020 were included in the observation group.An additional 99 patients who concurrently underwent physical examination were included in the control group.Serum immunoglobulin and IL-18 levels were detected in each group and they were compared between the two groups.Changes in serum immunoglobulin and IL-18 levels detected after treatment relative to before treatment were analyzed in the observation group.Results Serum levels of immunoglobulin A,immunoglobulin G,immunoglobulin M,and IL-18 in the observation group were(2.68±0.74)g/L,(15.24±4.17)g/L,(2.59±1.03)g/L,(2.53±0.21)ng/mL,respectively,which were significantly higher than those in the control group[(1.76±0.63)g/L,(11.58±3.46)g/L,(1.38±0.49)g/L,(1.68±0.34)g/L,respectively,t=9.45,6.74,10.54,21.36,all P<0.01).In the observation group,serum levels of immunoglobulin A,immunoglobulin G,immunoglobulin M,and IL-18 were(2.03±0.51)g/L,(13.12±3.25)g/L,(1.93±0.47)g/L,(1.74±0.15)μg/L after treatment,which were significantly lower than those before the treatment[(2.68±0.74)g/L,(15.24±4.17)g/L,(2.59±1.03)g/L,(2.53±0.21)μg/L,t=7.26,4.02,10.54,5.87,all P<0.01).Conclusion Serum immunoglobulin and IL-18 levels in combination can reflect the condition of viral hepatitis B patients and provide scientific reference for clinical treatment.The research results are scientific and innovative and are worthy of promotion.