复方甘菊利多卡因凝胶对灼口综合征患者状态焦虑的缓解作用

Alleviating effect of kamistad gel on state anxiety in patients with burning mouth syndrome

目的:探讨复方甘菊利多卡因凝胶对灼口综合征(BMS)患者疼痛和焦虑情绪的缓解作用。方法:纳入BMS患者30例,分为安慰剂组、阳性对照组和甘美达治疗组,根据统一的局部给药方法,连续使用2周。采用视觉模拟评分法(VAS)评估治疗前后疼痛情况,状态-特质焦虑问卷(STAI)评估治疗前后状态焦虑(S-AI)和特质焦虑(T-AI)水平。结果:基线水平VAS与患者S-AI呈正相关(r=0.695,P<0.05)。用药2周后,安慰剂、阳性对照组、甘美达治疗组的VAS均明显降低(P<0.05),且治疗后甘美达治疗组VAS显著低于其余两组(P<0.05)。治疗后,甘美达治疗组S-AI较治疗前下降(P<0.05),且与其他两组存在明显差异(P<0.05);而3组患者治疗后T-AI无明显差异,仅甘美达组较治疗前T-AI有所下降(P<0.05)。结论:甘美达能显著减轻BMS患者的疼痛,同时对患者的状态焦虑有明显的缓解作用。

Objective:To investigate the relieving effects of compound chamomile and lidocaine hydrochloride gel(Kamistad)on pain and anxiety in patients with burning mouth syndrome(BMS).Methods:Thirty patients with BMS were enrolled and divided into three groups:placebo group,positive control group and kamistad-treated group.They were given 6 times a day for 2 weeks according to a uniform local drug delivery method.Visual analogue score(VAS)was used to assess patients’pain before and after treatment.The state-trait anxiety inventory(STAI)was used to assess the levels of state anxiety(S-AI)and trait anxiety(T-AI)before and after treatment.Results:On baseline,VAS was positively correlated with SAI(r=0.695,P<0.05).After two weeks of treatment,VAS of placebo,positive control group and kamistad-treated group were decreased(P<0.05),and VAS of kamistad-treated group was significantly lower than that of the other two groups(P<0.05).In the meantime,S-AI in the kamistad-treated group decreased compared with before treatment(P<0.05),and there was significant difference between the other two groups(P<0.05),while T-AI in the three groups had no significant difference,and only the T-AI in the kamistad-treated group decreased compared with before treatment(P<0.05).Conclusion:Kamistad gel has a significant therapeutic effect on the pain of patients with BMS,and can obviously relieve the state anxiety of BMS patients.