利拉鲁肽对2型糖尿病患者血糖波动的影响——基于临床随机对照研究的Meta分析

Meta-analysis of the effects of liraglutide on blood glucose fluctuations in patients with type 2 diabetes mellitus

目的 系统评价利拉鲁肽对2型糖尿病(T2DM)患者血糖波动的影响。方法 以“利拉鲁肽、2型糖尿病、血糖波动”为中文检索词,以“type 2 diabetes mellitus、liraglutide、glucose variability”为英文检索词,检索中国知网、万方、维普、中国生物医学文献、PubMed、Embase、Web of Science、Cochrane Library数据库,检索时间从建库至2021年5月31日。收集应用利拉鲁肽治疗T2DM的国内外随机对照研究,提取相关数据,应用Revman 5.3软件进行Meta分析。结果 共纳入10篇文献,669例患者。Meta分析显示,T2DM患者应用利拉鲁肽治疗后平均血糖波动幅度可明显降低(MD=-1.42,95%CI:-1.75~-1.09,P<0.001)。结论 本研究表明,在临床治疗中,利拉鲁肽可有效减少T2DM患者血糖波动。

Objective To systematically evaluate the effects of liraglutide on blood glucose fluctuations in patients with type 2 diabetes mellitus( T2DM). Methods Searching well-known Chinese and foreign databases( CNKI, Wanfang Database, VIP,SinoMed,PubMed,Embase,Web of Science,and Cochrane Library) with the search terms "liraglutide, type 2 diabetes mellitus,glucose variability", from the establishment of the database to May 31,2021. We collected Chinese and foreign randomized controlled trials on the application of liraglutide in the treatment of T2DM, extracted relevant data, and used Revman 5.3 software for Meta-analysis. Results A total of 10 articles and 669 patients were included. Meta analysis showed that after treatment with liraglutide,the mean amplitude of glucose excursions of T2DM patients could be significantly decreased(MD =-1.42,95% CI:-1.75--1.09,P <0.001). Conclusion This study showed that liraglutide could reduce blood glucose fluctuations in patients with T2DM.