肿瘤间质成分及病理学特征在胃肿瘤中的研究进展

Research progress of tumor stroma ingredient and pathological features in gastric cancer

胃肿瘤间质的主要成分由免疫微环境和非免疫微环境中细胞共同组成。辅助治疗等系列措施的临床疗效均与胃肿瘤间质成分密切相关。通过分析胃肿瘤间质的成分,了解胃肿瘤病理学结构中组成成分特点,进一步探索间质各成分与病理学结构的联系及间质成分调节胃肿瘤发生、进展机制。结合人工智能技术对肿瘤微环境中间质成分相关病理学特征进行分析,有望揭示胃肿瘤免疫微环境与非免疫微环境的动态变化。

The main components of the gastric tumor stroma consist of cells in both the immune and non-immune microenvironments.The effectiveness of a series of therapeutic measures such as adjuvant chemotherapy is closely related to the composition of gastric tumor stroma.By analyzing the components in the gastric tumor stroma,we understand the characteristics of the constituents in the pathological structure of gastric cancer,and further explore the connection of each component of the stroma with pathological structure and regulatory mechanisms of stroma components on the occurrence and progression of gastric tumors.Combined with artificial intelligence technology to analyze the pathological features related to stroma components of tumor microenvironment,the dynamic changes of immune microenvironment and non-immune microenvironment in gastric cancer are expected to reveal.