妊高征患者予以硫酸镁联用硝苯地平治疗对血压的控制效果

Effect of Magnesium Sulfate Combined with Nifedipine on Blood Pressure Control in Patients with Pregnancy Induced Hypertension

目的分析妊高征(PIH)患者接受硫酸镁+硝苯地平治疗方案对控制患者血压的效果。方法此次研究所纳入的研究对象(n=100),是本院2019年7月至2020年12月收治的PIH患者。根据治疗方案不同进行分组,分为对照组(n=50,硫酸镁治疗)和试验组(n=50,硫酸镁+硝苯地平),分析观察两组治疗效果差异。结果两组血压控制有效率相比,对照组为82.00%,试验组为96.00%,试验组血压控制有效率较高(P<0.05);同治疗前相比,经治疗后患者的氧化应激指标、Hcy和胱抑素C水平均有显著改善,但试验组更明显(P<0.05);与治疗前相比,经治疗后患者的一氧化氮、血清内皮素-1和胰岛素样生长因子-1水平均有显著改善,但试验组改善幅度大于对照组(P<0.05);两组患者的不良反应发生率相比差异无统计学意义(P>0.05)。结论将硫酸镁+硝苯地平治疗方案应用于PIH治疗中,能有效控制患者血压,减轻患者氧化应激反应,不良反应较少,对于改善母婴不良结局有积极意义,值得应用。

Objective To analyze the effect of magnesium sulfate combined with nifedipine on the blood pressure in patients with pregnancy-induced hypertension(PIH).Methods A total of 100 PIH patients admitted to our hospital from July 2019 to December 2020 were selected to this study.According to different treatment options,they were divided into control group(n=50,magnesium sulfate treatment)and experimental group(n=50,magnesium sulfate+nifedipine),and the difference in treatment effect between the two groups was analyzed and observed.Results The effective rate of blood pressure control between the two groups was 82.00% in the control group and 96.00% in the experimental group.The effective rate of blood pressure control in the experimental group was higher(P<0.05);compared with before treatment,the oxidative stress of patients after treatment The indicators,Hcy and Cystatin C levels were significantly improved,but the experimental group was more obvious(P<0.05);compared with before treatment,the patient’s nitric oxide,serum endothelin-1 and insulin-like growth factor after treatment-1 levels were significantly improved,but the improvement in the experimental group was greater than that in the control group(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of magnesium sulfate combined with nifedipine therapy in PIH treatment can effectively control the blood pressure of patients and reduce the oxidative stress response of patients,reduce the incidence of adverse reactions.It has positive significance for improving the adverse outcomes of mothers and infants and is worthy of promotion.