妊娠期急性脂肪肝临床管理指南(2022)

Clinical management guidelines for acute fatty liver of pregnancy in China(2022)

妊娠期急性脂肪肝(AFLP)是一种罕见但病情危急的产科特有疾病,致死率高,对母儿安全构成严重威胁。为规范临床管理,改善母儿结局,特制订本指南。基于前期多次的临床问卷调查环节,指南制订小组确定了临床医师最关注的9个临床问题,并对其逐一给出了推荐意见,包括:AFLP的门诊筛查、诊断、术前风险评估、分娩方式选择、麻醉方式选择、围产期并发症、人工肝治疗的指征、预后的评估及治疗期间如何监测,涵盖了AFLP诊治相关的热点问题。

Acute fatty liver of pregnancy(AFLP)is a rare but critical obstetric disease with a high mortality rate,and it poses a serious threat to the safety of the mother and the child.The guidelines are developed to standardize clinical management and improve the outcome of the mother and the child.Based on multiple previous clinical questionnaire surveys,the guideline development group identified the nine clinical issues that clinicians are most concerned with and gave recommendations for each issue,including the outpatient screening for AFLP,diagnosis,preoperative risk assessment,selection of mode of delivery,selection of anesthesia method,perinatal complications,indication for artificial liver therapy,evaluation of prognosis,and monitoring during treatment,which covers the hot topics associated with the diagnosis and treatment of AFLP.