摘要
炎症小体在肝脏的天然免疫中发挥着重要作用,然而炎症小体的过度活化能够导致肝脏的炎症损伤,其中NLRP3炎症小体的损伤机制研究最为清楚。研究表明,多种肝脏疾病的发生可能均与炎症小体(尤其NLRP3炎症小体)的过度活化有关。本文将分别从炎症小体、NLRP3炎症小体的活化机制及其在不同肝脏疾病中的作用机制进行综述,以期从NLRP3炎症小体角度,为肝脏疾病的治疗靶点提供参考。
Inflammasomes play an important role in the innate immunity of the liver;however,the excessive activation of inflammasomes can lead to liver inflammation and injury.The mechanism of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome-mediated liver injury has been extensively studied.Related studies have shown that the development of various liver diseases may be associated with the excessive activation of inflammasomes,especially NLRP3 inflammasome.This article reviews inflammasomes,the activation mechanism of NLRP3 inflammasome,and the role of NLRP3 inflammasome in different liver diseases,so as to provide a reference for the treatment targets of liver diseases from the perspective of NLRP3 inflammasome.
作者
杨燕
葛斐林
黄倩
张馨月
曾锐
肖小河
柏兆方
孙琴
YANG Yan;GE Feilin;HUANG Qian;ZHANG Xinyue;ZENG Rui;XIAO Xiaohe;BAI Zhaofang;SUN Qin(School of Integrated Traditional Chinese and Western Medicine,Southwest Medical University,Luzhou,Sichuan 646000,China;School of Pharmacy,Southwest Medical University,Luzhou,Sichuan 646000,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100029,China;China Military Institute of Chinese Medicine,The Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China;Drug Research Center of Integrated Traditional Chinese and Western Medicine,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;National Traditional Chinese Medicine Clinical Research Base,The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2022年第4期942-946,共5页
Journal of Clinical Hepatology
基金
国家自然科学基金项目(8193000309)
四川省科学技术厅项目(2021YFH0150)
四川省中医药管理局项目(2017C012)。
