微小RNA-200c在胰腺癌中的研究进展

Research advances in microRNA-200c in pancreatic cancer

微小RNA-200c(miR-200c)是一类非编码小分子RNA,参与基因转录后水平调控,与肿瘤的发生发展密切相关。本文介绍了miR-200c对胰腺癌侵袭和转移的抑制作用,及其在胰腺癌的早期诊断、预后判断等方面的临床应用价值,提示miR-200c可作为抑癌基因及有效分子标志物和未来临床研究重点。

MicroRNA-200 c(miR-200 c)is a type of non-coding small molecule RNA,which is involved in the post-transcriptional regulation of genes and is closely associated with the development and progression of tumor.This article introduces the inhibitory effect of miR-200 c on the invasion and metastasis of pancreatic cancer and the clinical application value of miR-200 c in the early diagnosis and prognostic evaluation of pancreatic cancer.It is pointed out that miR-200 c can be used as a tumor suppressor gene and an effective molecular marker for further clinical research.