胰腺癌肿瘤微环境的机制及靶向治疗

Research advances in the mechanism of tumor microenvironment in pancreatic cancer and related targeted therapy

胰腺癌肿瘤微环境是一个包含胰腺星状细胞、癌相关成纤维细胞、免疫细胞和细胞外基质的过度纤维化的致密基质环境,不仅为肿瘤创造了促进其生长和侵袭的环境,并使其对化疗和其他抗肿瘤药物产生耐受抵抗。基质中密集纤维化反应和肿瘤在免疫环境中的改变被认为是目前胰腺癌治疗失败的主要原因。本文回顾了近年来胰腺癌肿瘤微环境相关研究进展,对其组成成分和致病机制以及针对基质和免疫的靶向治疗作一综述,分析肿瘤微环境对胰腺癌发生进展的重要性及其在靶向治疗方面的影响。

The tumor microenvironment of pancreatic carcinoma is a dense matrix environment with excessive fibrosis containing pancreatic stellate cells,cancer-associated fibroblasts,immune cells,and extracellular matrix,which not only creates an environment to promote the growth and invasion of tumors,but also makes them resistant to chemotherapy and other antitumor drugs.Intensive fibrosis reaction in the matrix and changes of tumors in immune environment are considered the main reasons for treatment failure in pancreatic cancer management.This article reviews the recent research advances in the tumor microenvironment of pancreatic cancer,summarizes its composition and pathogenesis and the targeted therapies for matrix and immune cells,and analyzes the importance of tumor microenvironment in the development and progression of pancreatic cancer and its impact on targeted therapy.