注射用鼠神经生长因子联合丁苯酞对急性脑梗死患者的疗效及血清因子的影响

Effect of murine nerve growth factor for injection combined with butylphthalide on acute cerebral infarction and serum factors

目的研究注射用神经生长因子联合丁苯酞对急性脑梗死患者的临床疗效和对血清因子的影响。方法选取于2015年1月~2020年1月治疗的50例急性脑梗死患者,按随机数表法分为观察组和对照组,各25例。对照组给予常规疗法联合丁苯酞治疗,观察组在对照组治疗基础上给予鼠神经生长因子注射治疗,比较两组的临床疗效、神经功能(NIHSS)评分、肢体运动功能(ADL)评分、血清超敏CRP(hs-CRP)、肿瘤坏死因子α(TNF-α)、神经元特异性烯醇化酶(NSE)及不良反应发生率。结果观察组治疗后的NIHSS评分低于对照组(P<0.05);观察组治疗后的ADL评分高于对照组(P<0.05);观察组治疗后的hs-CRP、TNF-α及NSE水平均低于对照组(P<0.05);观察组的治疗总有效率高于对照组(P<0.05),两组的不良反应发生率差异无统计学意义(P>0.05)。结论注射用鼠神经生长因子联合丁苯酞可显著降低急性脑梗死患者血清炎性因子水平及提高临床治疗有效率。

Objective To study the clinical efficacy of nerve growth factor for injection combined with butylphthalide on patients with acute cerebral infarction and the effect on serum factors.Methods Fifty patients with acute cerebral infarction admitted to the hospital from April 2020 to April 2021 were selected as the research objects.The selected patients were divided into the observation group and the control group by random number table method,with 25cases in each group.The control group was given conventional therapy combined with butylphthalide therapy,and the observation group was given mouse nerve growth factor injection on the basis of the control group.The clinical efficacy,neurological function(NIHSS)score,limb motor function(ADL)score,and serum.Hypersensitivity CRP(hs-CRP),tumor necrosis factorα(TNF-α),neuron-specific enolase(NSE)and the incidence of adverse reactions were compared between the two groups.Results The NIHSS score of the observation group after treatment was significantly lower than that of the control group(P<0.05),and the ADL score of the observation group after treatment was significantly higher than that of the control group(P<0.05);The NSE level was significantly lower than that of the control group(P<0.05),the total effective rate of treatment in the observation group was significantly higher than that of the control group(P<0.05),and the incidence of adverse reactions between the two groups was not significantly different(P>0.05).Conclusion The combination of mouse nerve growth factor for injection and butylphthalide can significantly reduce the level of serum inflammatory factors in patients with acute cerebral infarction and improve the effective rate of clinical treatment.