摘要
人工耳蜗(cochlear implants, CI)作为重度-极重度感音神经性耳聋的标准治疗方式,已被广泛接受。但许多因素影响CI植入效果,包括CI电极植入造成的机械性损伤,耳蜗内的炎症反应,组织纤维化和新骨形成,甚至电极表面纤维组织形成。这些因素损害残余螺旋神经节细胞、听毛细胞和血管纹细胞,并增加电阻抗。近年来,利用电极涂层降低这些不利因素对CI植入效果的影响已成为一个研究热点。如利用不同涂层包埋基因重组干细胞和药物或生长因子、神经营养因子,降低电极植入阻力,减少电极表面蛋白黏附,降低电极电阻抗等。本文将对近年来已研究的不同材料电极涂层特性进行综述。
Cochlear implants(CI) have become a well-accepted electronic device as the standard treatment for profound sensorineural hearing loss. However, many factors can affect CI performance, including tissue damage caused by insertion of the CI electrode array, inflammatory responses, fibrosis and new bone formation and growth of fibrous tissue on the electrode array surface. They not only affect residual spiral ganglion neurons, hair-cells and stria vascularis,but also increase CI impedance. In recent years, using electrode array coatings to reduce these negative effects has become the focus of research. Scholars used different coatings embeding genetically modified stem cells and encapsulate drugs, growth factors or neurotrophins, along with reduced insertion forces, to inhibit protein adhesion and reduce impedance of the electrode array. In this paper, we will review characteristics of different coating materials that have been currently researched.
作者
王旨意
付勇
WANG Zhiyi;FU Yong(Department of Otolaryngology Head and Neck Surgery,Children’s Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang,310000)
出处
《中华耳科学杂志》
CSCD
北大核心
2022年第2期334-338,共5页
Chinese Journal of Otology
基金
国家自然科学基金面上项目(82071038)~~。
关键词
人工耳蜗
涂层
材料
Cochlear implants
Coatings
Material