Connexin蛋白在老年性耳聋中作用的研究进展

Research Progress on the Role of Connexins in Presbycusis

随着社会老龄化的不断加快,老年性耳聋(年龄相关性听力损失)的发病率越来越高。它严重影响老年人的生活质量,还可能导致社会孤立、抑郁,甚至痴呆。老年性耳聋是一种极其复杂的多基因和多因素疾病。Connexin蛋白在内耳发育和维持正常听力过程中起着重要作用,它与老年性耳聋是密切相关的。本文就Connexin蛋白的表达在老年性耳聋中的作用作一综述。对Connexin蛋白与老年性耳聋关系的研究将有利于揭示各种因素导致老年性耳聋的机制,并为临床上防治老年性耳聋提供新的、有效的途径和方法。

With the acceleration of population aging, the incidence of presbycusis(Age-related hearing loss) also increases, which seriously affects the quality of life among the elderly and can lead to social isolation, depression and dementia. Presbycusis is considered an extremely complex, polygenic and multifactorial disease. Connexins play an important role in the development and maintenance of normal inner ear function and hearing and is closely related to presbycusis. This article reviews the role of connexins expression in presbycusis. which should help reveal the mechanism of presbycusis, and provide new and effective ways for effective prevention and treatment of presbycusis.