植物核糖体应激响应机制研究进展

A Review on the Mechanism of Ribosome Stress Response in Plants

核仁是真核细胞中重要的核结构,核糖体发生最初在核仁中进行,该过程涉及一系列复杂的反应,需要许多核仁相关因子参与。核糖体生物发生出现异常通常引起核仁结构紊乱,并导致细胞周期阻滞、细胞衰老甚至凋亡。核糖体应激响应机制在哺乳动物细胞中研究得较为深入,但在植物细胞中尚不明晰。尽管如此,人们逐渐发现某些植物特有的NAC转录因子家族成员在植物细胞中可能参与包括核糖体应激在内的多种胞内应激响应过程。此外,前期研究发现生长素系统与核糖体生物合成之间存在一种相互协调机制来调控植物发育。该文结合哺乳动物细胞中已知的核糖体应激响应通路,探讨植物细胞潜在的核糖体应激机制。

The nucleolus is a key structure in the nucleus of eukaryotic cells. Ribosome biogenesis initially takes place in the nucleolus, which involves a series of complex reactions and requires the participation of many nucleolus-associated factors. Abnormal ribosome biogenesis usually leads to disordered nucleolus structure, cell cycle arrest, cell senescence,and even cell death. The mechanism of ribosomal stress response has been studied well in mammals, while it remains largely unknown in plant cells. Nevertheless, it has been found that members of the plant-specific NAC transcription factor family are involved in various intracellular stress responses, including ribosomal stress, in plant cells. In addition, we previously reported a coordination mechanism between auxin system and ribosome biogenesis for modulating plant development. In this review, we discussed potential mechanisms of ribosome stress response in plant cells through combining the knowledge of ribosomal stress response pathways in mammals.