KLK14与恶性肿瘤转移关系的研究进展

Research progress on the relationship between KLK14 and malignant tumor metastasis

人组织激肽释放酶14(Kallikrein-related peptidase 14,KLK14)是人组织激肽释放酶家族(Kallikrein-related peptidases,KLKs)中的一员,广泛存在于多种组织及生物体液中,发挥着重要的生理作用。目前有研究表明KLK14可以作为多种恶性肿瘤诊断和预后的生物标志物,并且参与恶性肿瘤细胞增殖、侵袭、迁移等多种生物学功能的调控。KLK14作为一种分泌型丝氨酸蛋白酶,可以通过多种途径促进肿瘤细胞转移,而肿瘤转移是导致恶性肿瘤临床治疗失败以及患者死亡的主要原因。因此,本文将基于已有的研究就KLK14在肿瘤转移中的作用和可能机制进行综述,以期为恶性肿瘤的诊断及精准治疗提供新策略与新思路。

Kallikrein-related peptidase 14(KLK14)is a member of the Kallikrein-related peptidases(KLKs)family,a gene which widely exists in various tissues and biological fluids and plays an important physiological role.Current studies indicate that KLK14 can be used as a biomarker for the diagnosis and prognosis of multiple malignant tumors.A secretory serine protease,KLK14 can promote tumor cell metastasis through a variety of ways,and it is involved in the regulation of multiple biological functions such as proliferation,invasion,and migration of malignant tumor cells.Tumor metastasis is the main cause of failure of clinical treatment and death.Therefore,this paper discusses the role and possible mechanism of KLK14 in tumor metastasis based on a review of the existing literature,in order to provide new strategies and ideas for the diagnosis and accurate treatment of malignant tumors.