细胞焦亡在胃癌中的生物学作用研究进展

Research progress on biological role of pyrolysis in gastric cancer

细胞焦亡是依赖于Gasdermin家族蛋白诱导细胞质膜形成膜孔的可调控的细胞死亡,以质膜孔隙形成和促IL-18、IL-1炎症因子生成释放为表现。随着研究的深入,细胞焦亡在癌症中的生物学作用日益凸显。细胞焦亡各关键组分尤其是Gasdermin家族在癌症的发生发展中显示出关键作用。细胞焦亡与胃癌的关系复杂,一方面细胞焦亡可以抑制肿瘤的发生和发展;另一方面细胞焦亡作为促炎性死亡的一种,可以为肿瘤细胞的生长形成适宜的肿瘤微环境,从而促进胃癌的发生发展。因此,本文就细胞焦亡的分子机制、胃癌与细胞焦亡的相关研究探讨该生物学过程在胃癌中的作用,以期为胃癌的诊疗提供新的思路。

Pyroptosis is the programmed cell death that relies on Gasdermin family proteins to induce the formation of pores in the plasma membrane of the cell,resulting in the production and release of IL-18 and IL-1 inflammatory factors.With the advances in research,the biological role of pyroptosis in cancer has become increasingly prominent.The key components of pyroptosis,especially the Gasdermin family,play an important role in the occurrence and development of cancer.The relationship between pyroptosis and gastric cancer is complicated.While pyroptosis can inhibit the occurrence and development of tumors,it can also,through pro-inflammatory death,form a suitable microenvironment for the growth of tumor cells,thereby promoting tumor growth.Therefore,this article explores the role of pyroptosis and its molecular mechanism in gastric cancer,to provide new ideas for its diagnosis and treatment.