基于音乐的运动疗法对帕金森患者平衡功能障碍作用的meta分析

Music-based Movement Therapy Ameliorates Balance Function in Parkinson Disease:A Meta-Analysis

目的:在现有文献的基础上通过meta分析技术评估基于音乐的运动疗法对帕金森患者平衡功能障碍的影响,并探讨可能影响其效果的潜在因素。方法:截止到2021年7月,检索数据库(pubmed、Embase、Web of Science、Cochrane Library、中国知网、维普及万方),纳入符合标准的随机对照实验研究,计算95%置信区间的标准化均数差,采用CMA2.0软件进行meta分析。结果:源于17篇文献共计670名被试符合标准,纳入的文献质量评价结果良好。Meta分析的结果显示:基于音乐的运动疗法对PD患者平衡功能影响的合并效应量为1.384,(95%CI[0.826,1.942],p<0.001),属于大效应。在meta回归中,较低的年龄与较大平衡功能改善相关(β=-0.19;95%CI:-0.25 to 0.12;p<0.05);在亚组分析中,干预类型、干预周期以及干预频率三个潜在的调节变量对平衡功能不存在显著的影响。结论:本研究综合评估发现基于音乐的运动疗法可能对PD患者的平衡功能具有改善作用;年龄越低,平衡功能的改善越好。

Objectives:To evaluate the effects of music-based movement therapy on balance dysfunction among parkinson disease by meta-analysis based on available literature,and to explore the potential factors that may influence their effects.Methods:Seven databases(pubmed,Embase,Web of Science,Cochrane Library,CNKI,VIP and Wanfang database)were systematically searched up to July 2021,only the randomized controlled trials that meet our inclusion criteria were collected.Standardized Mean Differences with a 95%confidence interval was used to calculate the summary estimates using Comprehensive Meta-Analysis software 2.0.Results:A total of 670 subjects from 17 articles were eligible for inclusion and the included studies overall quality was good.The results showed an overall large effect sizes for music-based movement therapy on balance function in parkinson disease(SMD=1.384;95%CI,0.826 to 1.942,p<0.001).In meta regression,younger age associated with larger efect size(β=-0.19,95%CI:0.25 to 0.12,p<0.05);In the subgroup analysis,the moderating effect of intervention characteristics(type,duration and frequency)was not found to be significant.Conclusions:The pooled evidence suggests that music-based movement therapy may have a general facilitative effect on balance function in parkinson’s disease.Younger age was associated with greater improvements in balance function.