银杏达莫注射液辅助治疗老年脑梗死患者的疗效及其对认知功能、血液流变学的影响

Efficacy of ginkgo leaf extract and dipyridamole injection in adjuvant treatment of senile patients with cerebral infarction and its effects on cognitive function and hemorheology

目的探讨银杏达莫注射液辅助治疗老年脑梗死患者的临床疗效及对患者认知功能、血液流变学的影响。方法选取2018年1月至2020年1月我院收治的老年脑梗死患者96例为研究对象,采用随机数字法分为对照组(46例)和研究组(50例)。对照组患者接受脑梗死的常规治疗,研究组患者在对照组基础上加用银杏达莫注射液辅助治疗。检测比较两组患者治疗前后神经功能、认知功能;比较两组患者的临床疗效;检测比较两组患者治疗前后的血浆黏度(PV)、全血高切黏度(HBV)、纤维蛋白原(Fb)水平、全血低切黏度(LBV)。结果治疗前,两组患者的美国国立卫生研究院卒中量表(NIHSS)评分、简易智能状态量表(MMSE)评分比较,差异无统计学意义(P>0.05);治疗3周后,研究组患者的NIHSS评分显著低于对照组,MMSE评分显著高于对照组,差异有统计学意义(P<0.05)。研究组患者的治疗总有效率(94.00%)显著高于对照组(80.43%),差异有统计学意义(P<0.05)。治疗前,两组患者的PV、HBV、Fb、LBV水平比较,差异无统计学意义(P>0.05);治疗3周后,研究组患者的PV、HBV、Fb、LBV水平均显著低于对照组,差异有统计学意义(P<0.05)。结论银杏达莫注射液辅助治疗可有效改善老年脑梗死患者的神经功能及认知功能,显著提高患者的临床疗效,明显改善患者的血液流变学状况,值得推广应用。

Objective To investigate the clinical efficacy of ginkgo leaf extract and dipyridamole injection in adjuvant treatment of senile patients with cerebral infarction and its effects on cognitive function and hemorheology.Methods A total of 96 senile patients with cerebral infarction admitted to our hospital from January 2018 to January 2020 were selected as the research objects,and they were divided into control group(46 cases)and study group(50 cases)by the random number method.The control group received conventional treatment of cerebral infarction,whereas the study group received ginkgo leaf extract and dipyridamole injection on the basis of the control group.The neurological function and cognitive function were detected and compared between the two groups before and after treatment.The clinical efficacy of the two groups was compared.Plasma viscosity(PV),whole blood high shear viscosity(HBV),fibrinogen(Fb)level and whole blood low shear viscosity(LBV)were detected and compared between the two groups before and after treatment.Results The national institute of health stroke scale(NIHSS)score and mini-mental state examination(MMSE)score showed no statistically significant differences between the two groups before treatment(P>0.05).After 3 weeks of treatment,patients in the study group had significantly lower NIHSS score and higher MMSE score in comparison with the control group,with statistically significant significances(P<0.05).The total effective rate in the study group(94.00%)was significantly higher than that in the control group(80.43%),with a statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in the levels of PV,HBV,Fb,and LBV between the two groups(P>0.05).After 3 weeks of treatment,the indicators mentioned above in the study group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Ginkgo leaf extract and dipyridamole injection adjuvant treatment can effectively improve the neurological function and cognitive function of senile patients with cerebral infarction,significantly improve the clinical efficacy and hemorheological condition of patients,which is worthy of popularization and application.