乳腺癌患者E-钙黏附蛋白、肌切蛋白的表达水平与新辅助化疗疗效的相关性

Correlation between the expression of E-cadherin and scinderin in breast cancer patients and the effect of neoadjuvant chemotherapy

目的研究乳腺癌患者E-钙黏附蛋白、肌切蛋白的表达水平与新辅助化疗效果的关系。方法选取2017年4月至2020年4月陕西省核工业二一五医院收治的78例乳腺癌患者为研究对象,所有患者均接受新辅助化疗结合手术治疗,持续化疗4个周期,于化疗结束后评价临床疗效,根据评价效果将临床完全缓解、病理完全缓解、临床部分缓解患者纳入疗效较好组(n=51),临床稳定、临床进展者纳入疗效较差组(n=27)。比较两组患者的临床特征以及治疗前后的E-钙黏附蛋白、肌切蛋白水平和E-钙黏附蛋白、肌切蛋白阳性表达率;E-钙黏附蛋白、肌切蛋白与新辅助化疗疗效的相关性采用Pearson相关分析。结果疗效较差组患者的淋巴结转移率为88.88%,远高于疗效较好组的11.76%,差异具有统计学意义(P<0.05);治疗后,疗效较差组患者的E-钙黏附蛋白和肌切蛋白平均积分光密度值分别为(25.58±5.13)%和(21.42±5.21)%,明显高于疗效较好组的(21.01±5.15)%和(15.98±5.18)%,差异均具有统计学意义(P<0.05);疗效较差组患者的E-钙黏附蛋白和肌切蛋白阳性率分别为92.59%、96.29%,明显高于疗效较好组的47.05%、43.13%,差异均具有统计学意义(P<0.05);经Pearson相关性分析结果显示,E-钙黏附蛋白(r=-0.095,P<0.01)、肌切蛋白(r=-4.27,P=0.031)表达与新辅助化疗疗效均呈负相关。结论乳腺癌患者体内E-钙黏附蛋白、肌切蛋白参与了乳腺癌的发展,且E-钙黏附蛋白、肌切蛋白与新辅助化疗疗效均呈负相关。

Objective To study the relationship between the expression of E-cadherin and scinderin in breast cancer patients and the effect of neoadjuvant chemotherapy.Methods A total of 78 breast cancer patients admitted to No.215 Hospital of Shaanxi Nuclear Industry from April 2017 to April 2020 were selected as the research objects.All patients received neoadjuvant chemotherapy combined with surgical treatment and continued chemotherapy for 4 courses.After chemotherapy,the clinical efficacy was evaluated.According to the evaluation results,patients with complete clinical remission,complete pathological remission,and partial clinical remission were included in the better efficacy group(n=51),and those with clinical stability and clinical progress were included in the poor efficacy group(n=27).The clinical characteristics of the two groups were compared,as well as the serum levels and the positive expression rates of E-cadherin and scinderin before and after treatment.The correlation between E-cadherin,scinderin and the efficacy of neoadjuvant chemotherapy was analyzed by Pearson correlation analysis.Results The lymph node metastasis rate of patients in the poor efficacy group was 88.88%,which was much higher than 11.76% in the better efficacy group(P<0.05).After treatment,the average integrated optical density values of E-cadherin and scinderin of patients in the poor efficacy group was(25.58±5.13)% and(21.42±5.21)%,respectively,which was significantly higher than corresponding(21.01±5.15)% and(15.98±5.18)%in the better efficacy group(P<0.05).The positive rates of E-cadherin and scinderin in the poor efficacy group were 92.59% and 96.29%,respectively,which were significantly higher than 47.05% and 43.13% in the better efficacy group(P<0.05).Pearson correlation analysis showed that the expression of E-cadherin(r=-0.095,P<0.01)and scinderin(r=-4.27,P=0.031)were negatively correlated with the efficacy of neoadjuvant chemotherapy.Conclusion E-cadherin and scinderin in breast cancer patients are involved in the development of breast cancer,and the expression of E-cadherin and scinderin are negatively correlated with the efficacy of neoadjuvant chemotherapy.