甲状腺功能亢进症合并肝损伤的病因诊断及治疗进展

Diagnosis and treatment of patients with hyperthyroidism and liver injury

甲状腺功能亢进症合并肝损伤在临床上较常见,肝损伤的病因、发病机制及临床表现复杂。高水平甲状腺素、抗甲状腺药物及合并其他肝脏疾病可通过不同机制引起肝损伤,临床上表现为不同程度肝损伤,极个别患者可进展为肝衰竭危及生命。但临床上甲状腺功能亢进症合并肝损伤的病因诊断较困难,治疗也缺乏有效的手段。本文对甲状腺功能亢进症合并肝损伤患者的临床特征、诊断及治疗进行综述,以期帮助临床医生提高关于甲状腺功能亢进症合并肝损伤患者的处理水平。

Patients with hyperthyroidism and liver injury are common in clinic practice.The etiology,pathogenesis and clinical manifestations of liver injury are complex.High levels of thyroid hormones,antithyroid drugs,and other liver diseases can cause liver damage through different mechanisms.Clinically,liver damage is manifested in varying degrees,and very few patients can progress to life-threatening liver failure.But it is difficult to diagnose the cause of liver injury in patients with hyperthyroidism,and there is a lack of effective treatment methods.This article reviews the clinical features,diagnosis and treatment of patients with hyperthyroidism and liver injury,in order to help clinicians improve the management of patients with hyperthyroidism and liver injury.