金双歧联合思密达治疗小儿腹泻的临床效果分析

Clinical effect analysis of Golden Bifid combined with Smecta in the treatment of infantile diarrhea

目的分析双歧杆菌乳杆菌三联活菌片(商品名:金双歧)联合蒙脱石散(商品名:思密达)治疗小儿腹泻的临床效果。方法80例小儿腹泻患儿,根据治疗方案不同分为对照组和实验组,每组40例。对照组行金双歧治疗,实验组行金双歧联合思密达治疗。对比两组临床疗效、症状改善时间、不良反应发生情况。结果实验组患儿的治疗总有效率为97.50%(39/40),显著高于对照组的82.50%(33/40),差异具有统计学意义(P<0.05)。实验组患儿的腹泻、发热、腹痛改善时间分别为(2.58±0.23)、(1.23±0.23)、(1.46±0.25)d,均显著短于对照组的(3.47±0.52)、(2.85±0.36)、(2.58±0.36)d差异具有统计学意义(P<0.05)。实验组患儿的不良反应发生率2.50%(1/40)低于对照组的15.00%(6/40)差异具有统计学意义(χ^(2)=3.9139,P=0.0479<0.05)。结论金双歧联合思密达治疗小儿腹泻可帮助患儿缓解腹痛、腹泻、发热等临床症状,缩短治疗时间,进一步提高临床效果,加强肠道屏障作用,提高患儿肠屏障免疫力,且不会增加患儿的不良反应,安全性高,更能满足患儿的临床治疗需求,疗效确切,值得应用与推广。

Objective To analyze the clinical effect of live combined bifidobacterium and lactobacillus tablets(trade name:Golden Bifid)combined with montmorillonite powder(trade name:Smecta)in the treatment of infantile diarrhea.Methods A total of 80 cases of infantile diarrhea were divided into control group and experimental group according to different treatment schemes,with 40 cases in each group.The control group was treated with Golden Bifid,and the experimental group was treated with Golden Bifid combined with Smecta.The clinical efficacy,symptom improvement time,and occurrence od adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 97.50%(39/40),which was significantly higher than 82.50%(33/40)of the control group,and the difference was statistically significant(P<0.05).The improvement time of diarrhea,fever and abdominal pain in the experimental group were(2.58±0.23),(1.23±0.23),and(1.46±0.25)d,which were significantly shorter than(3.47±0.52),(2.85±0.36),and(2.58±0.36)d in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 2.50%(1/40)in the experimental group was lower than 15.00%(6/40)in the control group,and the difference was statistically significant(χ^(2)=3.9139,P=0.0479<0.05).Conclusion Golden Bifid combined with Smecta has definite efficacy in the treatment of infantile diarrhea,and can help children relieve abdominal pain,diarrhea,fever and other clinical symptoms,shorten the treatment time,further improve the clinical effect,strengthen the intestinal barrier,improve the immunity of the intestinal barrier without increasing the adverse reactions of children.It has high safety,and can better meet the clinical treatment needs of children,which is worthy of application and promotion.