阿奇霉素结合左氧氟沙星治疗宫颈炎患者的疗效评价

Evaluation of the efficacy of azithromycin combined with levofloxacin in the treatment of cervicitis

目的分析阿奇霉素结合左氧氟沙星治疗宫颈炎的效果。方法70例宫颈炎患者,根据随机数字表法将所有患者分为研究组和对照组,各35例。对照组予以阿奇霉素片治疗,研究组在对照组基础上加用左氧氟沙星治疗。比较两组患者临床疗效、治疗前后的血清炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、不良反应发生情况、复发率。结果研究组治疗总有效率97.14%高于对照组的80.00%,差异具有统计学意义(P<0.05)。治疗后,研究组患者IL-6(7.69±1.23)ng/L、TNF-α(18.76±2.59)ng/L、CRP(3.28±0.75)mg/L均低于对照组的(13.42±2.38)ng/L、(26.38±3.87)ng/L、(5.36±1.42)mg/L,差异均具有统计学意义(P<0.05)。研究组不良反应发生率11.43%与对照组的8.57%比较,差异无统计学意义(P>0.05)。研究组复发率5.71%低于对照组的22.86%,差异具有统计学意义(χ^(2)=4.200,P<0.05)。结论宫颈炎应用阿奇霉素与左氧氟沙星联合治疗,能够有效减轻患者炎性反应,提升患者治疗效果,且不良反应少,复发率低,可推广应用。

Objective To analyze the effect of azithromycin combined with levofloxacin in the treatment of cervicitis.Methods A total of 70 patients with cervicitis were divided into the research group and the control group according to the random numerical table,with 35 cases in each group.The control group was treated with azithromycin tablets,and the research group was additionally treated with levofloxacin on the basis of the control group.Both groups were compared in terms of clinical efficacy,serum inflammatory factor levels[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]before and after treatment,occurrence of adverse reactions,and recurrence rate.Results The total effective rate 97.14% of the research group was higher than 80.00% of the control group,and the difference was statistically significant(P<0.05).After treatment,the IL-6(7.69±1.23)ng/L,TNF-α(18.76±2.59)ng/L,and CRP(3.28±0.75)mg/L in the research group were lower than(13.42±2.38)ng/L,(26.38±3.87)ng/L,and(5.36±1.42)mg/L in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions 11.43% in the research group was not statistically significant compared with 8.57% in the control group(P>0.05).The recurrence rate 5.71% of the research group was lower than 22.86%of the control group,and the difference was statistically significant(χ^(2)=4.200,P<0.05).Conclusion The combined application of azithromycin and levofloxacin in the treatment of cervicitis can effectively reduce the inflammatory reaction of patients,improve the therapeutic effect of patients with less adverse reactions and low recurrence rate,which can be widely promoted and applied in clinical practice.