碳酸酐酶抑制剂联合美开朗治疗青光眼的疗效分析

Efficacy analysis of carbonic anhydrase inhibitor combined with Mikelan in the treatment of glaucoma

目的探讨碳酸酐酶抑制剂联合盐酸卡替洛尔滴眼液(商品名:美开朗)治疗青光眼的疗效。方法60例青光眼患者,按随机数字表法分为对照组和观察组,每组30例。对照组患者给予美开朗治疗,观察组患者给予碳酸酐酶抑制剂联合美开朗治疗。比较两组患者临床疗效及用药前、用药后各时间段(用药后第2 d、用药后1周、用药后2周、用药后4周)眼压水平。结果观察组患者治疗总有效率为96.67%,显著高于对照组的76.67%,差异具有统计学意义(P<0.05)。用药前,两组患者的眼压水平比较差异无统计学意义(P>0.05);用药后第2 d,观察组患者的眼压水平(19.23±2.20)mm Hg(1 mm Hg=0.133 kPa)明显低于对照组的(22.25±2.35)mm Hg,差异具有统计学意义(P<0.05);用药后1、2、4周,两组患者的眼压水平比较差异无统计学意义(P>0.05)。结论碳酸酐酶抑制剂联合美开朗治疗青光眼的疗效显著,能够快速降低眼压,并使眼压长时间趋于稳定。

Objective To discuss the efficacy of carbonic anhydrase inhibitor combined with carteolol hydrochloride eye drops(trade name:Mikelan)in the treatment of glaucoma.Methods A total of 60 cases of glaucoma patients were randomly divided into control group and observation group,with 30 cases in each group.Patients in the control group were treated with Mikelan,while patients in the observation group were treated with carbonic anhydrase inhibitor in combination with Mikelan.The clinical efficacy and intraocular pressure levels before and after medication(the 2nd day after medication,1 week after medication,2 weeks after medication,and 4 weeks after medication)were compared between the two groups.Results The total effective rate in the observation group was 96.67%,which was significantly higher than 76.67% in the control group,and the difference was statistically significant(P<0.05).Before medication,there was no statistically significant difference in intraocular pressure between the two groups(P>0.05);On the 2nd day after medication,the intraocular pressure level(19.23±2.20)mm Hg(1 mm Hg=0.133 kPa)of the observation group was significantly lower than(22.25±2.35)mm Hg of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in intraocular pressure between the two groups at 1,2,and 4 weeks after medication(P>0.05).Conclusion Carbonic anhydrase inhibitor combined with Mikelan has significant efficacy on the treatment of glaucoma,which can rapidly reduce intraocular pressure and stabilize intraocular pressure for a long time.