自拟中药灌肠方联合美沙拉嗪治疗溃疡性结肠炎的临床效果观察

Clinical effect of self-made traditional Chinese medicine enema prescription combined with mesalazine in the treatment of ulcerative colitis

目的研究溃疡性结肠炎患者采用自拟中药灌肠方联合美沙拉嗪治疗的临床效果。方法80例溃疡性结肠炎患者,采用随机数字表法分为对照组及观察组,每组40例。对照组采用美沙拉嗪治疗,观察组在对照组的基础上联合自拟中药灌肠方治疗。对比两组患者的临床疗效,对比两组患者的丙二醛(MDA)、超氧化物歧化酶(SOD)、C反应蛋白(CRP)水平。结果治疗后,观察组患者的总有效率95.00%高于对照组的75.00%,差异具有统计学意义(P<0.05)。观察组患者的MDA(5.98±0.55)nmol/ml、CRP(5.22±0.49)mg/L低于对照组的(6.77±0.61)nmol/ml、(6.18±0.76)mg/L,SOD(1.61±0.42)U/ml高于对照组的(1.27±0.33)U/ml,差异具有统计学意义(P<0.05)。结论给予溃疡性结肠炎患者自拟中药灌肠方联合美沙拉嗪联合治疗,可有效消除炎症,改善临床症状,值得在临床推广应用。

Objective To study the clinical effect of self-made traditional Chinese medicine enema prescription combined with mesalazine in the treatment of ulcerative colitis. Methods A total of 80 patients with ulcerative colitis were divided into control group and observation group by random numerical table method, with 40 cases in each group. The control group was treated with mesalazine, and the observation group was treated with self-made traditional Chinese medicine enema prescription on the basis of the control group. The clinical efficacy, malondialdehyde(MDA), superoxide dismutase(SOD), and C-reactive protein(CRP) were compared between the two groups. Results After treatment, the total effective rate 95.00% of the observation group was higher than 75.00% of the control group, and the difference was statistically significant(P<0.05). The MDA(5.98±0.55) nmol/ml and CRP(5.22±0.49) mg/L of the observation group were lower than(6.77±0.61) nmol/ml and(6.18±0.76) mg/L of the control group, and the SOD(1.61±0.42) U/ml was higher than(1.27±0.33) U/ml of the control group. All the differences were statistically significant(P<0.05). Conclusion Combination of self-made traditional Chinese medicine enema and mesalazine can effectively eliminate inflammation and improve clinical symptoms, which is worthy of clinical promotion and application.