BRCA1在同源重组修复中的作用

The role of BRCA1 in homologous recombination

在综述同源重组(homologous recombination,HR)修复途径的过程及其产物的基础上,重点介绍BRCA1蛋白结构及其在HR修复途径中的2个主要功能:一是促进DNA末端切除,二是介导重组酶RAD51在DSB位点处的装载。指出乳腺癌和卵巢癌相关基因BRCA1所表达的蛋白参与DNA损伤修复,在HR修复途径中发挥重要作用。最后介绍了近年来Brca1基因突变小鼠的胚胎发育与挽救的相关研究进展。

On the basis of reviewing the process and products of homologous recombination(HR)repair pathway,this paper focused on the structure of BRCA1 protein and its two main functions in HR repair pathway:one is to promote DNA end resection,the other is to mediate the loading of the recombinase RAD51 at the DSB site.It was pointed out that the protein expressed by the breast and ovarian cancer-related gene BRCA1 was involved in DNA damage repair and played an important role in the HR repair pathway.Finally,the research progress of embryonic development and rescue of Brca1 mutant mice in recent years was introduced.