感染因素与子痫前期发生相关性的研究进展

Research progress of the correlation between infection factors and preeclampsia

子痫前期是妊娠期特有疾病,多种学说试图阐明其发病机制,但均不能完全解释该病的发生发展。近年来有学者提出感染因素在子痫前期发生发展过程中可能起到一定的作用。本文对可能引起子痫前期发生的致病微生物进行综述,阐述其证据及可能的发病机制,主要病原体包括人巨细胞病毒、新型冠状病毒、乙型肝炎病毒、幽门螺杆菌、引起牙周炎细菌、解脲支原体、肺炎衣原体及疟疾等。

Preeclampsia is a unique disease in pregnancy.Many theories try to clarify its pathogenesis,but they can not fully explain the occurrence and development of the disease.In recent years,some scholars have proposed that infection factors may play a role in the occurrence and development of preeclampsia.This paper reviews the pathogenic microorganisms that may cause preeclampsia,and expounds its ev idence and possible pathogenesis.The main pathogens include human cytomegalovirus,novel coronavirus,hepatitis B virus,Helicobacter pylori,causing periodontitis bacteria,Ureaplasma urealyticum,Chlamydia pneumoniae and mala ria.