阿莫西林-克拉维酸钾序贯疗法在学龄前儿童反复下呼吸道感染治疗中的价值

Value of Amoxicillin Clavulanate Potassium Sequential Therapy in the Treatment of Recurrent Lower Respiratory Tract Infection in Preschool Children

目的探讨阿莫西林—克拉维酸钾序贯疗法在学龄前儿童反复下呼吸道感染治疗中的价值。方法在新郑市人民医院范围内,以2019年3月至2020年3月为时间节点,选取患有反复下呼吸道感染的学龄前患儿70例,按照随机数字表法将其分成两组,对照组37例始终采用阿莫西林-克拉维酸钾行静滴治疗;观察组33例给予阿莫西林—克拉维酸钾先静滴治疗,待病情维稳后,改用阿莫西林-克拉维酸钾片口服治疗,直到症状均消失。就两组治疗效果及治疗期间不良反应发生情况及外周血T细胞亚群水平(CD3^(+)、CD8^(+)、CD4^(+)/CD8^(+))进行比较。结果观察组治疗有效率(96.97%)较之对照组(78.38%)明显偏高,差异有统计学意义(P<0.05)。观察组不良反应发生率(6.06%)与对照组(16.22%)相比,显著偏低,差异有统计学意义(P<0.05)。观察组血清CD3^(+)、CD4^(+)/CD8^(+)相比对照组均明显升高,有统计学意义(P<0.05),而血清CD8^(+)显著降低,差异有统计学意义(P<0.05)。结论针对学龄前反复下呼吸道感染患儿,采用阿莫西林-克拉维酸钾行序贯治疗,效果好,不良反应少,一定程度上利于患儿免疫功能的改善。

Objective To explore the value of amoxicillin clavulanate potassium sequential therapy in the treatment of recurrent lower respiratory tract infection in preschool children.Methods A total of 70 preschool children with recurrent lower respiratory tract infection were selected from March 2019 to March 2020 within the scope of our hospital.They were divided into two groups according to the random number table method.In the control group,37 cases were always treated with intravenous drip of amoxicillin clavulanate potassium.In the observation group,33 cases were treated with intravenous drip of amoxicillin clavulanate potassium first.After the condition was stable,Use amoxicillin clavulanate potassium tablets orally until the symptoms disappear.The therapeutic effects,adverse reactions and peripheral blood T cell subsets(CD3^(+),CD8^(+),CD4^(+)/CD8^(+))were compared between the two groups.Results The total effective rate of the observation group(96.97%)was significantly higher than that of the control group(78.38%)(P<0.05).The incidence of adverse reactions in the observation group(6.06%)was significantly lower than that in the control group(16.22%)(P<0.05).Serum CD3^(+),CD4^(+)/CD8^(+)in the observation group were significantly higher than those in the control group(P<0.05),while serum CD8^(+)was significantly lower(P<0.05).Conclusion For preschool children with recurrent lower respiratory tract infection,sequential treatment with amoxicillin clavulanate potassium has good effect and less adverse reactions,which is conducive to the improvement of children's immune function to a certain extent.