基于数据挖掘的《中华医典》治疗银屑病内服方药规律研究

Analysis of the rule of prescription of Chinese Medical Code in the treatment of psoriasis based on traditional Chinese medicine inheritance support system

目的:基于中医传承辅助平台V2.5软件分析《中华医典》中治疗银屑病的内服方的组方用药规律。方法:收集《中华医典》收录古籍中所载的治疗银屑病的内服方,利用中医传承辅助平台建立数据库,分析组方的用药特点及规律。结果:筛选出方剂共33条,其中共涉及107味中药,药性多为苦、甘、辛,多归肝、脾、胃经,分析得出用药以防风、大黄、当归为主。支持度≥6的中药药对组合为9对;分析熵层次聚类分析得到6组治疗银屑病的新处方。结论:通过中医传承辅助平台揭示《中华医典》治疗银屑病处方用药规律,治则上多从清热解毒,养血活血,祛风除湿等入手,挖掘出的新方可为后续临床银屑病内服药选择提供参考。

Objective:To analyze the regularity of internal prescription of Chinese Medical Code in the treatment of psoriasis based on traditional Chinese medicine inheritance support platform V2.5(TCMISP V2.5)software.Methods:The internal prescriptions for the treatment of psoriasis recorded in Chinese Medical Code were collected and their medication characteristics were analyzed.Results:Total 107 kinds of herbs were involved in 33 prescriptions and their medicinal properties are mostly bitter,sweet and pungent and belong to the liver,spleen and stomach meridian.The common herbs were mainly Fangfeng(Radix saposhnikoviae),Dahuang(Radix et rhizoma rhei),Danggui(Radix angelicae sinensis).There were 9 herb pairs with support degree≥6,and 6 groups of new prescriptions for the treatment of psoriasis were obtained by unsupervised entropy cluster analysis.Conclusion:Through the TCMISP,the rules of prescriptions for the treatment of psoriasis are revealed in the Chinese Medical Code.The treatment is mostly from clearing away heat and detoxification,nourishing blood and promoting blood circulation,dispelling wind and removing dampness.The mined new prescription can provide reference for the follow-up selection of clinical oral medicine for psoriasis.