复方嗜酸乳杆菌联合含铋剂四联疗法在Hp感染性消化性溃疡中的应用效果分析

Clinical Efficacy Analysis of Compound Eosinophil-Lactobacillus Tablets Combined with Bismuth Quadruple Therapy in the Treatment of Hp-induced Peptic Ulcer

目的 分析探讨复方嗜酸乳杆菌联合含铋剂四联疗法治疗幽门螺杆菌(Hp)感染性消化性溃疡的临床效果方法 选取2020年1月至2020年12月郑州市第七人民医院收治的100例HP感染性消化性溃疡患者作为研究对象,按照随机数表法将其随机分为观察组(50例)与对照组(50例),观察组患者采用复方嗜酸乳杆菌联合阿莫西林胶囊+奥硝唑片+复方铝酸铋颗粒+雷贝拉唑钠肠溶片的联疗法治疗,对照组患者单纯采用阿莫西林胶囊+奥硝唑片+复方铝酸铋颗粒+雷贝拉唑钠肠溶片的四联疗法治疗,对比两组患者血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平以及生存质量与焦虑、抑郁评分变化情况。结果治疗2周后,观察组患者IL-1、IL-6及CRP水平均明显低于对照组(t=7.949、6.913、9.987,P均<0.001);治疗结束后3个月随访时,观察组患者世界卫生组织生存质量测定量表简表(WHOQOL-BREF)各评分均明显高于对照组(t=5.132、5.290、4.687、6.182,P均<0.001),焦虑自评量表(SAS)与抑郁自评量表(SDS)评分均明显低于对照组(t=15.730、11.503,P均<0.001)。结论 与单纯应用含铋剂四联疗法相比,复方嗜酸乳杆菌联合含铋剂四联疗法可明显减轻Hp感染性消化性溃疡患者的炎症反应,提高患者生存质量,缓解患者焦虑抑郁情绪。

Objective To study the clinical efficacy of Compound Eosinophil-Lactobacillus Tablets combined with Bismuth quadruple therapy(BQT) in the treatment of peptic ulcer induced by Helicobacter Pylori(Hp).Methods 100 patients with Hp-induced peptic ulcer,admitted into The 7 th People’s Hospital of Zhengzhou between January 2020 and December 2020,were enrolled as research subjects,and divided into observation group(n=50) and control group(n=50) using the random number table.Patients in observation group were treated with Compound Eosinophil-Lactobacillus Tablets combined with Bismuth quadruple therapy(BQT)-Amoxicillin Capsules+Ornidazole Tablets+Compound Bismuth Aluminate Granules+Rabeprazole Sodium Enteric-coated Tablets,whereas patients in control group were treated with Bismuth quadruple therapy(BQT) only.Changes of serum interleukin-1(IL-1),interleukin-6(IL-6),C-reaction protein(CRP),quality of life,and anxiety and depression score were compared between the two groups.Results 2 weeks after treatment,the levels of IL-1,IL-6 and CRP in observation group were all remarkably lower than control group(t=7.949,6.913 and 9.987,all P <0.001).The follow-up 3 months after treatment found that WHOQOL-BREF scores of patients in observation group were all obviously higher than control group(t=5.132,5.290,4.687 and 6.182,all P <0.001),while the self-rating anxiety scale(SAS) and self-rating depression scale(SDS) scores were significantly lower than control group(t=15.730 and 11.503,both P <0.001).Conclusion Compared with the application of BQT,the combined application of Compound Eosinophil-Lactobacillus Tablets and BQT in the treatment of Hp-induced peptic ulcer can significantly relieve patients’ inflammatory reactions,improve their quality of life and ameliorate their anxiety and depression.