结直肠癌死亡患者的肿瘤转移部位、发生率及预后

Location,Patternand Prognosis of Tumor Metastasisin Dead Patientswith Colorectal Cancer

【目的】既往有多个报道结直肠癌转移方式的研究,但尚缺少基于长期随访并以死亡作为观察终点,总结CRC转移部位、发生率以及相关生存数据的研究。【方法】本研究回顾中山大学附属第六医院373例结直肠癌死亡患者资料,统计分析肿瘤转移的部位、发生率以及生存资料。【结果】334例(89.5%)患者为肿瘤相关性死亡,肝转移率为51.5%,肺转移率为40.4%,腹膜转移率为55.7%。单纯肝、肺、腹膜转移患者数分别为27例(8%)、21例(6.3%)、63例(18.9%)。单纯肺转移患者生存明显优于单纯肝转移或单纯腹膜转移(P<0.01)。肝肺腹膜同时转移的患者共66例(19.7%)且预后最差(P<0.01)。【结论】并非所有死亡结直肠癌患者都会出现肝肺腹膜同时转移。不同患者的转移方式存在差异,并与生存相关。

【Objective】In the past,many studies have reported the mode of colorectal cancer(CRC)metastasis,but there is still a lack of research based on long-term follow-up and death as the end point to summarize the location,mode and related survival data of CRC metastasis.【Methods】The data of 373 dead patients with colorectal cancer in the Sixth Af⁃filiated Hospital of Sun Yat-sen University were reviewed,and the location,mode,incidence and survival data of tumor metastasis were statistically analyzed.【Results】334 patients(89.5%)died of tumor related death.The liver metastasis rate was 51.5%,the lung metastasis rate was 40.4%,and the peritoneal metastasis rate was 55.7%.The number of patients with liver,lung or peritoneal metastasis only was 27(8%),21(6.3%)and 63(18.9%)respectively.The prognosis of pa⁃tients with simple lung metastasis was better(P<0.01).There were 66 patients(19.7%)with simultaneous metastasis of liver,lung and peritoneum,and the prognosis was the worst(P<0.01).【Conclusion】Not all dead colorectal cancer pa⁃tients have simultaneous metastasis of liver,lung and peritoneum.There are differences in the location and mode of metas⁃tasis in different patients,which is related to survival.