丙硫氧嘧啶和甲巯咪唑对甲亢治疗的临床应用效果比较分析

Comparative Analysis of the Clinical Application Effect of Propylthiouracil and Methimazole in the Treatment of Hyperthyroidism

目的讨论丙硫氧嘧啶和甲巯咪唑对甲亢治疗的临床应用效果。方法选取2020年3月—2021年5月该院收治的50例甲亢患者为研究对象,随机分为对照组(丙硫氧嘧啶)与研究组(甲巯咪唑),各25例。比较两组患者疗效、甲状腺功能、肝功能、不良反应发生率。结果研究组疗效总有效率为96.00%,明显高于对照组的68.00%,差异有统计学意义(χ^(2)=4.878,P<0.05)。治疗后,研究组促甲状腺激素水平(4.36±1.92)mU/L高于对照组,三碘甲状腺原氨酸(3.21±0.05)nmol/L、游离三碘甲状腺原氨酸(9.13±1.10)pmol/L、游离甲状腺素水平(15.05±1.23)pmol/L低于对照组,差异有统计学意义(t=6.606、4.850、3.067、5.205,P<0.05)。治疗后,研究组谷丙转氨酶(35.39±2.18)U/L、谷草转氨酶(32.38±3.19)U/L、碱性磷酸酶(110.56±2.84)U/L、总胆红素(10.46±2.35)μmol/L低于对照组,差异有统计学意义(t=8.381、5.715、5.140、2.172,P<0.05)。研究组不良反应发生率为4.00%,明显低于对照组的32.00%,差异有统计学意义(χ^(2)=4.878,P<0.05)。结论相较于丙硫氧嘧啶,甲巯咪唑治疗甲亢病症疗效较高,更利于改善患者的甲状腺功能及肝功能,减轻药效治疗不良反应。

Objective To discuss the clinical effect of propylthiouracil and methimazole in the treatment of hyperthyroidism.Methods Fifty patients with hyperthyroidism who were admitted to the hospital from March 2020 to May 2021 were selected as the research objects,and they were randomly divided into the control group(propylthiouracil)and the study group(methimazole),25 cases in each.The curative effect,thyroid function,liver function and incidence adverse reactions were compared between the two groups.Results The total effective rate of the study group was 96.00%,which was significantly higher than 68.00%of the control group,and the difference was statistically significant(χ^(2)=4.878,P<0.05).After treatment,the level of TSH in the study group was(4.36±1.92)mU/L higher than that in the control group,triiodothyronine(3.21±0.05)nmol/L,free triiodothyronine(9.13±1.10)pmol/L and free thyroxine levels(15.05±1.23)pmol/L were lower than those in the control group,and the difference was statistically significant(t=6.606,4.850,3.067,5.205,P<0.05).After treatment,in the study group,alanine aminotransferase(35.39±2.18)U/L,aspartate aminotransferase(32.38±3.19)U/L,alkaline phosphatase(110.56±2.84)U/L,total bilirubin(10.46±2.35)μmol/L was lower than the control group,and the difference was statistically significant(t=8.381,5.715,5.140,2.172,P<0.05).The incidence of adverse reactions in the study group was 4.00%,which was significantly lower than 32.00%in the control group,and the difference was statistically significant(χ^(2)=4.878,P<0.05).Conclusion Compared with propylthiouracil,methimazole has a higher curative effect in the treatment of hyperthyroidism,and is more conducive to improving the thyroid function and liver function of patients,and reducing the adverse reactions of drug efficacy treatment.