摘要
Atherosclerotic cardio-cerebral vascular disease is the most common disease that threatens human health.Many researches indicated that oxidatively modified low-density lipoprotein[ox-LDL]is a key pathogenic factor of atherosclero-sis.Here,we report the change of the secondary structure of ox-LDL caused by photoirradiation in an optofluidic resonator.The content ratios of amphipathic o-helices and β-sheets of ox-LDL are changed under laser beam ilumination,resulting in an increasing binding rate of ox-LDL and ox-LDL antibodies.Our findings may provide a potential way for clinical athero-sclerosis treatment and prompt recovery rate of atherosclerotic cardio-cerebral vascular disease by optical technology and immunotherapy.
作者
Yuxi Shang
Hailang Dai
Daopeng qai
jinmao Gu
Meng Zhang
Qiheng Wei
Xianfeng Chen
尚宇晞;戴海浪;戴道鹏;顾进茂;张萌;魏麒恒;陈险峰(State Key Laboratory of Advanced Optical Communication Systems and Networks,School of Physics and Astronomy,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Cardiology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200240,China;The Affiliated Hospital of Tianjin Chinese Medical Institute,Tongji University,Shanghai 200092,China;Shanghai Research Center for Quantum Sciences,Shanghai 201315,China;Jinan Institute of Quantum Technology,Jinan 250101,China;Collaborative Innovation Center of Light Manipulation and Applications,Shandong Normal University,Jinan 250358,China)
基金
This work was supported by the National Key R&D Program of China(No.2018YFA0306301)
the National Natural Science Foundation of China(NSFC)(Nos.11734011,11764020,and 12104298)
the China Postdoctoral Science Foundation(Nos.2020M681275 and 2021T140452)
the Foundation for Shanghai Municipal Science and Technology Major Project(No.2019SHZDZX01-ZX06).
