Fibulin蛋白家族在肿瘤发生、发展及化疗耐药中的研究进展

Progress of Fibulin protein family in tumor development,progression and chemotherapy resistance

人纤维蛋白家族是一类广泛在各组织中表达的细胞外基质(ECM)蛋白,并在ECM的形成及稳定中发挥重要作用。越来越多的研究发现,Fibulin蛋白家族在不同的肿瘤组织中可分别起到抑癌或促癌的作用,从而影响肿瘤的增殖、侵袭、转移,并与肿瘤的化疗耐药密切相关,有希望成为临床抑制甚至逆转肿瘤化疗耐药的靶点。文章就Fibulin蛋白家族在肿瘤发生、发展及化疗耐药中的作用、靶点及分子机制进行综述,旨在为肿瘤化疗耐药找寻新的研究方向。

Fibulin protein family is a class of extracellular matrix(ECM)proteins that are widely expressed in various tissues and plays an important role in the formation and stabilization of ECM.More and more studies have found that Fibulin protein family can play a role in tumor suppression or tumor promotion in different tumor tissues,which affects tumor proliferation,invasion and metastasis and is closely related to tumor chemotherapy resistance.Furthermore,Fibulin protein family is expected to be the target of inhibiting and reversing tumor chemotherapy resistance.This article reviews the role,target and molecular mechanism of Fibulin protein family in tumor development,progression and chemotherapy resistance,aiming to find a new research direction for tumor chemotherapy resistance.