摘要
γ突触核蛋白(SNCG)因在多种恶性肿瘤中特异性的过表达而被广泛研究。目前发现SNCG参与了雌激素、AKT-mTOR、丝裂原活化蛋白激酶(MAPK)和微管调节等多种信号通路,并与肿瘤细胞的增殖、侵袭、迁移以及化疗药物耐药性等密切相关,有望成为抗肿瘤、提高肿瘤细胞对化疗药物敏感性的关键靶点。
γ-synuclein(SNCG)has been extensively studied for its specific overexpression in various malignant neoplasms.Recently,SNCG has been found to be involved in multiple signaling pathways,including estrogen,AKT-mTOR,mitogen-activated protein kinase(MAPK)and microtubule regulation.SNCG has also been found to be related to the proliferation,invasion,migration and chemotherapy drug resistance of neoplasms.Therefore,SNCG is expected to be the key target of anti-tumor and improving the sensitivity of tumor cells to chemotherapeutic drugs.
作者
唐峰
龙浩
张燕
孙婷婷
袁伟
Tang Feng;Long Hao;Zhang Yan;Sun Tingting;Yuan Wei(Department of Ophthalmology and Otorhinolaryngology,63650 Hospital of PLA,Urumqi 841700,China;Department of Otorhinolaryngology Head and Neck Surgery,Southwest Hospital,Army Medical University,Chongqing 400038,China;Department of Otorhinolaryngology Head and Neck Surgery,Chongqing General Hospital,University of Chinese Academy of Sciences,Chongqing 400013,China)
出处
《肿瘤研究与临床》
CAS
2022年第2期154-157,共4页
Cancer Research and Clinic
基金
国家自然科学基金 (81873702、81470694)。
关键词
γ突触核蛋白
肿瘤
细胞增殖
抗药性
肿瘤
γ-synuclein
Neoplasms
Cell proliferation
Drug resistance,neoplasm
